在怀孕56-66天采取胆样本后,严重的四肢异常
H V Firth1, P A Boyd, P Chamberlain
1Department of Medical Genetics, Churchill Hospital, Oxford, UK.
Lancet (London, England)
|March 30, 1991
概括
在怀孕初期采取胆样本 (CVS) 可能与新生儿的严重四肢异常有关. 需要进一步的研究来确认CVS是否是这些发育缺陷的原因.
科学领域:
- 医学遗传学 医学遗传学
- 产前诊断 在产前诊断
- 发育生物学 发展生物学
背景情况:
- 胆取样 (CVS) 是一种常见的产前诊断程序.
- 早期出现的四肢异常是严重的先天性疾病.
研究的目的:
- 调查胆取样 (CVS) 与严重四肢异常之间的潜在关联.
- 评估 CVS 后口腔关节代综合征和横截肢缩小缺陷的发生率.
主要方法:
- 在怀孕56-66天之间进行CVS的289个怀孕的回顾性分析.
- 在后代严重的肢体异常的识别和分类.
主要成果:
- 在289个被诊断为CVS的怀孕中,发现了5例严重四肢异常.
- 四名婴儿出现了口四肢降生综合征.
- 一名婴儿患有末期横截肢缩小缺陷.
结论:
- 在CVS后观察到严重四肢异常的发生率高于预期.
- 这些发现表明CVS在这些发育异常中可能起着病因作用.
- 需要进一步的研究来证实CVS和四肢形之间的因果关系.
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