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相关概念视频

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

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Published on: January 2, 2013

作为血型发育因子受体的EGF-R:c-erbB产物存在于的红细胞祖先中,并控制它们的自我更新.

B Pain1, C M Woods, J Saez

  • 1Laboratoire de Biologie Moléculaire et Cellulaire, CNRS INRA, Ecole Normale Supérieure de Lyon, France.

Cell
|April 5, 1991
PubMed
概括

编码表皮生长因子受体 (EGF-R) 的c-erbB基因控制正常红细胞祖先的自我更新. 这一发现揭示了c-erbB在调节细胞增殖和分化中的直接作用.

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科学领域:

  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学
  • 在瘤学瘤学.

背景情况:

  • c-erbB基因编码表皮生长因子受体 (EGF-R),这是细胞生长的关键调节器.
  • EGF-R放大与各种人类癌症有关,包括表皮和质瘤.
  • 之前,c-erbB在正常红色素形成中的作用尚不清楚.

研究的目的:

  • 为了研究c-erbB在正常的红细胞原始体中的功能.
  • 为了确定c-erbB在涉及TGFα的代信号通路中的作用.
  • 阐明红细胞原始体的增殖和分化之间的关系.

主要方法:

  • 对正常肉红细胞前代的c-erbB表达的分析.
  • 用TGFα,胰岛素和红色素治疗原始体.
  • 评估细胞增殖,自我更新和终端分化.

主要成果:

  • c-erbB存在于正常的红细胞原始体中,并从TGFα传递来自TGFα的线索信号.
  • 转化生长因子α (TGFα) 诱导长期更新表达高亲缘关系EGF-R的祖先.
  • 这些原始细胞在添加胰岛素和红蛋白后最终分化为红细胞.

结论:

  • c-erbB在控制正常红细胞原始体的自我更新方面发挥着直接作用.
  • 在这些细胞中,增殖和分化不一定是合的过程.
  • 这些发现可能解释了 erbB基因的白血病产生潜力.