临床研究中的出版偏见
P J Easterbrook1, J A Berlin, R Gopalan
1Division of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Lancet (London, England)
|April 13, 1991
概括
出版偏见在研究中是显而易见的,显著的发现更有可能被发表. 这影响了公布数据的可靠性,特别是在观察性研究中,需要更好的策略来找到所有研究结果.
科学领域:
- 医学研究伦理学医学研究伦理学
- 生物统计学 生物统计学
- 研究诚信研究诚信
背景情况:
- 发表偏见,即发表积极结果而不是负面结果的倾向,可能会扭曲科学理解.
- 伦理审查委员会批准了许多研究项目,但其出版成果并不总是透明的.
研究的目的:
- 调查中央伦理委员会批准的研究项目的出版偏见的存在和程度.
- 确定影响研究成果发表的因素.
主要方法:
- 在1984年至1987年间批准的487个研究项目的回顾性分析.
- 对285项分析研究的出版状况和相关因素进行了审查.
- 使用调整的赔率比率 (OR) 和95%置信区间 (CI) 来评估显著性.
主要成果:
- 52%的分析研究被发表.
- 从统计学上显著的结果被公布的可能性是两倍以上 (OR 2.32).
- 与随机临床试验 (OR 0.84) 相比,观察性和实验室研究显示出版偏差的倾向更高 (OR 3.79).
结论:
- 在一组临床研究中证实了出版偏见的存在.
- 研究结果表明,当仅仅从已公布的数据中解释结论时,特别是在观察性研究中,应该谨慎.
- 强调需要改进的策略来识别已发表和未发表的研究结果.
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