作为儿童感染的风险因素的孕产妇 filarial 感染
P J Lammie1, W L Hitch, E M Walker Allen
1Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Lancet (London, England)
|April 27, 1991
概括
孕产妇感染显著增加了儿童 filarial 感染的风险. 这项在海地进行的研究揭示了感染母亲的孩子更容易感染 filariasis,并表现出改变的免疫反应.
科学领域:
- 热带医学是一种热带医学.
- 寄生虫学的寄生虫学
- 免疫学 免疫学 免疫学
背景情况:
- 班克罗夫斯虫病在海地莱奥根等特有地区是一个重大的公共卫生问题.
- 了解 filarial 感染的传播动态和风险因素对于有效的控制策略至关重要.
研究的目的:
- 为了研究 filarial 感染的家族聚类.
- 确定母亲和父亲感染状况在儿童 filarial 感染风险中的作用.
- 评估母亲感染与儿童寄生虫特异性免疫反应之间的关联.
主要方法:
- 在海地一个流行病地区,对643个人进行了户外调查.
- 记录了母亲,父亲和儿童的感染状况.
- 测量了非性特异性细胞响应在非性非性儿童.
主要成果:
- 与未感染母亲的孩子相比,感染母亲的孩子感染 filariasis 的可能性是2.4至2.9倍.
- 父亲感染状况对儿童感染风险没有显著影响.
- 患有感染的母亲所生的微粒细胞血症的孩子比未感染的母亲所生的孩子表现出较低的细粒细胞特异性细胞反应能力.
结论:
- 孕产妇 filarial 感染是感染后代的重要危险因素.
- 怀孕期间母亲感染可能会影响发育中的免疫系统,导致对寄生虫的免疫反应发生改变.
- 这些发现强调了母亲健康在 filariasis 传播中的重要性,并表明了潜在的代际免疫效应.
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