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利巴维林治疗慢性C型肝炎的治疗方法

O Reichard¹, J Andersson, R Schvarcz

¹Department of Infectious Diseases, Karolinska Institute, Danderyds Hospital, Stockholm, Sweden.

Lancet (London, England)

|May 4, 1991

概括

口服里巴维林在治疗慢性C型肝炎感染方面表现有前途. 这项试点研究发现,治疗期间肝酶显著下降,并有轻微的副作用.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
药理学药理学是指药理学的学科.

背景情况:

慢性型肝炎病毒 (HCV) 感染是全球重要的健康问题.
慢性型肝炎目前的治疗选择有局限性.
非A,非B型肝炎,现在被称为C型肝炎,需要有效的治疗策略.

研究的目的:

评估口服里巴维林作为治疗慢性型肝炎的疗效和安全性.
评估瑞巴维林对慢性型肝炎患者肝酶水平的影响.
确定利巴维林作为C型肝炎的口服治疗剂的潜力.

主要方法:

试点研究涉及10名活检证明慢性非A,非B型肝炎的患者.
患者每天服用1000-1200毫克口服里巴维林,持续12周.
在治疗前,治疗期间和治疗后监测血清氨酸胺转移酶 (ALT) 水平.

主要成果:

在利巴维林治疗12周后,观察到ALT水平中位数显著下降 (p < 0.005).
在治疗后6周内,ALT水平恢复到治疗前的度.
报告的副作用是轻微的,在停止利巴维林后可以逆转.

结论:

口服里巴维林显示出作为慢性型肝炎有效治疗的潜力.
利巴维林是第一种口服药物,在治疗慢性型肝炎方面表现有前途.
需要在受控试验中进行进一步的研究,可能将利巴维林与干扰素α结合起来.

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