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鉴定甲型肝炎病毒是可感应个体自身免疫性慢性1型肝炎的触发因素
S Vento1, T Garofano, G Di Perri
1Infectious Diseases Unit, A. Pugliese Hospital, Catanzaro, Italy.
Lancet (London, England)
|May 18, 1991
概括
甲型肝炎病毒 (HAV) 感染可以在易受感染的个体中引发自身免疫性慢性活性肝炎 (CAH). 控制对肝细胞表面抗原的免疫反应的T淋巴细胞缺陷在HAV感染后的CAH发展之前.
科学领域:
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
背景情况:
- 自免疫性慢性活性肝炎 (CAH) 的发病因子仍然不完全理解.
- 识别自身免疫性肝病的触发因素对于开发向疗法至关重要.
研究的目的:
- 调查甲型肝炎病毒 (HAV) 感染作为自身免疫性CAH的潜在触发者的作用.
- 在易受感染的个体中识别自免疫CAH发展前的免疫因素.
主要方法:
- 预期跟踪58名健康亲属的13名患者自免疫CAH4年.
- 对血清学标记物和T淋巴细胞迁移抑制活性的监测.
- 在HAV感染之前和之后对亚洲糖蛋白受体 (ASGPR) 的免疫反应的分析.
主要成果:
- 在研究期间发生了三起亚临床急性甲型肝炎病例.
- 在两个患有自身免疫性CAH的受试者中,发现了针对ASGPR的抑制诱导T淋巴细胞的先前存在的缺陷.
- 在感染HAV后,这些受试者表现出持续且增加的特异性辅助T细胞和ASGPR抗体,导致5个月内发生自身免疫CAH1型.
结论:
- 甲型肝炎病毒 (HAV) 感染可以作为自身免疫性慢性活性肝炎 (CAH) 在遗传敏感个体的触发因素.
- 针对肝细胞抗原的T淋巴细胞调节的特定缺陷可能会使个体易于发展自身免疫性CAH后HAV感染.
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