器官特异性心脏抗体:在自身免疫性多体内膜病变中,系统性高血压的血清标志物
A L Caforio1, R Wagner, J S Gill
1Department of Cardiological Sciences, St George's Hospital Medical School, London, UK.
自身免疫多核突发病患者通常具有器官特异性心脏自身抗体. 这些抗体可能表明高血压的自身免疫性原因,即使没有心脏病症状.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 器官特异性自身抗体信号内分泌组织损伤和潜在的荷尔蒙失衡.
- 心脏表现出内分泌功能,分泌诸如心房 natriuretic (ANP) 等激素.
研究的目的:
- 在患有自身免疫多体内膜异位症的患者中调查器官特异性心脏自身抗体的存在.
- 在这个患者群体中探索心脏自身抗体和全身高血压之间的关联.
主要方法:
- 分析了来自166名自身免疫多胞膜病变患者,80名单腺自身免疫患者和200名健康对照者的血清样本.
- 人类心脏组织上的免疫光被用来检测心脏自身抗体;骨肌肉作为交叉反应的控制.
主要成果:
- 与单腺自身免疫患者 (1%) 和健康对照组 (3.5%) 相比,在自身免疫多腺核病患者 (17%) 中,器官特异性心脏自身抗体的患病率显著更高.
- 患有自身免疫多性腺核病症和心脏自身抗体的患者显示,全身高血压的患病率更高 (18%vs. 3%) 和家族高血压史 (42%vs. 7%).
- 在抗体阳性和阴性患者或对照人群之间没有观察到ANP水平的显著差异,尽管一些抗体阳性患者的ANP水平异常,与高血压无关.
结论:
- 自身免疫性多核突发病患者可能会产生器官特异性心脏自身抗体.
- 这些心脏自身抗体可以作为系统性高血压的自身免疫病因的新型血清学标记,即使没有明显的心脏病.
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