用瘤激活的杀手淋巴细胞对转移性结直肠癌进行成像
R I Swift1, H J Danpure, S Osman
1Department of Surgery, Hammersmith Hospital London, UK.
Lancet (London, England)
|June 22, 1991
概括
瘤激活杀手 (TAK) 淋巴细胞是由结直肠癌患者开发的,并用Indium-111标记以可视化转移. 这种采用免疫疗法方法成功地揭示了肺部和腹部的转移部位,有助于癌症分期.
科学领域:
- 在瘤学瘤学.
- 免疫疗法是一种免疫疗法.
- 医疗成像医学成像
背景情况:
- 收养免疫疗法为癌症治疗和可视化提供了潜力.
- 转移性结直肠癌需要有效的检测和分期方法.
研究的目的:
- 评估印-111标记的瘤激活杀手 (TAK) 淋巴细胞在可视化转移性结直肠癌中的实用性.
- 评估自主TAK细胞在识别转移性病变中的有效性.
主要方法:
- 从6名转移性结直肠癌患者中分离出了淋巴细胞.
- 瘤激活杀手 (TAK) 淋巴细胞是通过培养患者淋巴细胞与自身原发性瘤细胞生成的.
- 用印第安-111标记TAK细胞并重新注射到患者体内.
- 在注射后长达48小时内进行了玛摄像头成像.
主要成果:
- 转移在肺部早在4小时就可视化,在腹部早在48小时就可视化.
- 肝转移出现在成像上的"冷"斑点.
- 淋巴结没有被可视化.
- 重新注射自身的TAK细胞成功地揭示了转移性部位.
结论:
- 印-111标记的TAK细胞在可视化转移性结直肠癌方面是有效的.
- 这种采用免疫治疗方法有助于识别转移的位置.
- 基于TAK细胞的成像为转移性结直肠癌患者的癌症分期提供了宝贵的工具.
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