通过对NMDA受体的抗剂扰乱视网膜原酸的 afferent 分离
1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Nature
|June 13, 1991
概括
目标神经元活动塑造视觉系统的发展. 阻断N-甲基-D-酸盐 (NMDA) 受体在侧面生殖细胞核 (LGN) 中扰乱了视网膜输入的分离,表明后突触活动对适当的神经电路形成至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 视觉系统研究 视觉系统研究
背景情况:
- 在发育中的哺乳动物视觉系统中,对形成连接至关重要.
- 目标神经元活动在塑造 afferent 终结模式中的作用仍然不清楚.
- 视网膜质细胞轴突分离成眼睛特异的膜在侧面生殖细胞核 (LGN).
研究的目的:
- 研究后突触神经元活动对发育视觉系统中 afferent输入和突触结构的模式的影响.
- 为了确定阻断N-甲基-D-酸盐 (NMDA) 受体是否会影响视网膜 afferents 分离到特定的LGN内亚胺.
主要方法:
- 利用特定的抗剂阻断LGN细胞上的N-甲基-D-酸盐 (NMDA) 受体在亚胺形成的关键时期.
- 观察并分析了LGN内部的视网蛋白化轴突终端树的结果模式.
主要成果:
- 阻断NMDA受体阻止了视网膜 afferents 分离到"开启"和"关闭"的亚胺基.
- 视网原蛋白质轴突表现出不适当的树木化,要么不受正确的限制,要么错误地放置在眼睛特定的膜内.
- 抗NMDA受体降低了LGN细胞活性和视网原蛋白传递.
结论:
- 通过NMDA受体信号检测到的 postsynaptic 活动对于精确的 afferent 输入模式和视觉系统发育期间的 presynaptic afferents 的结构组织至关重要.
- LGN神经元的活动在指导功能神经回路的形成方面发挥着重要作用.
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