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Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

泰士河地区孕产妇艾滋病毒-1感染的患病率:匿名未关联新生儿检测结果

A E Ades¹, S Parker, T Berry

¹Epidemiology and Biostatistics Unit, Institute of Child Health and Hospitals for Sick Children, London, UK.

Lancet (London, England)

|June 29, 1991

概括

英格兰的人类免疫缺陷病毒 (HIV) 监测显示,伦敦内区以外的新生儿的患病率稳定. 然而,伦敦市中心的HIV-1抗体显著增加,突出显示了未被发现的异性传播.

科学领域:

流行病学流行病学
公共卫生公共卫生
传染性疾病传染性疾病

背景情况:

监测人类免疫缺陷病毒 (HIV) 在异性恋人群中的传播对于公共卫生干预至关重要.
新生儿查计划提供了一个独特的机会来追踪母亲艾滋病毒感染的趋势.

研究的目的:

监测英格兰异性恋社区内HIV-1感染的流行率和趋势.
评估当前对母亲艾滋病毒感染的认识和识别的有效性.

主要方法:

分析了1988年6月至1991年3月期间收集的新生儿查 (Guthrie卡) 的323,369个干血斑点.
在来自英格兰东北,西北和西南泰士河地区的样本中检测HIV-1的抗体.
伦敦内区与伦敦外区和非大都会地区的流行率的比较.

主要成果:

新生儿的HIV-1患病率在伦敦郊区和非大都市地区保持稳定.
在伦敦市中心的患病率显著增加,从2000年1人 (1988年6月至1989年5月) 增加到500人中的1人 (1991年前3个月).
产科医生仅在20%的感染怀孕中意识到母亲感染艾滋病毒,这表明普遍存在缺乏认可.

结论:

伦敦内区显示,异性恋人口中HIV-1患病率的增加令人担忧,这可能是由于指数式或线性增长.
在医疗保健提供者对孕产妇艾滋病毒感染的认可方面存在很大的差距,这强调了需要改进查和提高认识的需要.
新生儿查数据为跟踪异性恋社区艾滋病毒趋势提供了有价值的工具.

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