低度臭氧对喘患者吸入过敏原反应的影响
N A Molfino1, S C Wright, I Katz
1Department of Medicine, University of Toronto, Ontario, Canada.
Lancet (London, England)
|July 27, 1991
概括
暴露于低水平的臭氧显著增加了喘息患者对过敏原的呼吸道反应. 这种臭氧对喘症状的影响不会改变基线肺功能.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 过敏 免疫学 免疫学
背景情况:
- 臭氧和过敏原都会导致呼吸道炎症,可能会影响喘.
- 了解环境臭氧和过敏反应之间的相互作用对于喘管理至关重要.
研究的目的:
- 为了调查低水平的臭氧暴露是否会在喘患者中强化呼吸道过敏反应.
- 为了确定臭氧是否会影响支气管对吸入过敏原的反应.
主要方法:
- 七名阿托皮性喘患者接受了甲胆挑战和过敏原吸入测试.
- 在吸入过敏原或安慰剂之前,受试者暴露在空气或0.12 ppm臭氧中1小时.
- 气道反应性是通过引起FEV1 (PC15) 15%下降所需的过敏原度来衡量的.
主要成果:
- 臭氧暴露没有显著改变基线1秒内强迫呼气体积 (FEV1).
- 臭氧吸入后PC15显著减少,随后是过敏原,表明反应性增加 (PC15平均值:臭氧后0.0056毫克/毫升与空气后0.013毫克/毫升).
结论:
- 在城市地区常见的低水平臭氧暴露,增强了无氧喘患者对过敏原的支气管反应能力.
- 臭氧对过敏反应的这种强化发生在基线气道功能没有变化的情况下.
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