新生儿心血管自主功能障碍的证据与大动脉缩的新生儿
Jaimie W Polson1, Naomi McCallion, Hidefumi Waki
1Department of Clinical Sciences at South Bristol, School of Medical Sciences, Bristol Heart Institute, University of Bristol, Bristol, United Kingdom.
Circulation
|June 14, 2006
概括
患有主动脉缩 (CoA) 的新生儿表现出异常的自主心血管功能,包括血压升高和降低巴罗反射灵敏度. 这些早期的自主性变化可能会导致以后的高血压风险.
科学领域:
- 心血管生理学心血管生理学
- 新生儿医学 新生儿医学
- 自主神经系统功能 自主神经系统功能
背景情况:
- 大动脉缩 (CoA) 与治疗后持续高血压和血压控制问题有关.
- 新生儿对CoA的修复并没有防止随后的血压异常.
- 自主心血管功能的早期病理调整可能发生在COA新生儿中.
研究的目的:
- 为了调查是否新生儿与大动脉缩表现出自主心血管功能障碍的早期迹象.
- 为了比较COA新生儿与健康新生儿的自主心血管功能.
主要方法:
- 研究了8名新生儿使用简单的CoA和13名健康对照.
- 使用心电图和测序方法测量了自发性巴罗反射灵敏度.
- 使用非侵入性血压监测评估心率变化 (时间和频率域) 和血压变化 (频率域).
主要成果:
- 与对照组相比,患有CoA的新生儿血压升高 (78.9 mmHg与67.1 mmHg相比).
- CoA 婴儿表现出压抑的巴罗反射灵敏度 (8.7 与 13.8 ms/mm Hg 相比) 和心率变化降低 (16.5 与 31.5 ms2).
- 在新生儿患有CoA (3.1对2.2毫米Hg2) 的新生儿中观察到血压变化的高频成分增加.
结论:
- 患有大动脉缩的婴儿在自主心血管平衡中表现出病态调整.
- 这些发现表明,COA新生儿的自主性变化可能会在晚期高血压之前发生.
- 需要进一步的纵向研究来证实这些变化在患高血压的风险中的作用.
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