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双盲,受控,交叉研究,对严重耐火性亚托皮性皮肤炎的成年人进行环素
J M Sowden1, J Berth-Jones, J S Ross
1Dermatology Department, University Hospital, Nottingham, UK.
Lancet (London, England)
|July 20, 1991
概括
当其他治疗失败时,环素显著改善了成人严重的亚托皮性皮炎. 虽然出现了副作用,但环素在耐火病例中短期使用时被证明是安全有效的.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学 是一个学科.
背景情况:
- 严重的耐火性亚托皮性皮肤炎显著影响成年患者,尽管传统疗法.
- 对于严重的亚托皮性皮肤炎的成年人来说,仅有有限的治疗选择,对全身类固醇,阿扎西奥普林和光化疗无反应.
研究的目的:
- 评估环素在患有严重耐火性亚托皮性皮肤炎的成年人中的疗效和安全性.
- 评估环素对疾病活动,程度和患者报告的症状的影响.
主要方法:
- 这是一项双盲,安慰剂控制的交叉研究,涉及33名患有严重耐火性亚托皮性皮炎的成年患者.
- 患者在八周的治疗期间接受了安慰剂,其次是环素 (5毫克/千克/天) 或相反.
- 疾病活动,程度,睡眠,,局部类固醇使用和不良事件每两周监测一次.
主要成果:
- 对皮肤炎的程度和活性 (p < 0.001) 和主观措施的显著改善与cyclosporin.
- 20名接受环素治疗的患者报告了不良事件,而安慰剂治疗的8名患者报告了不良事件,但没有出现退出.
- 环素增加了平均血清尿素,肌和胆红素,胆红素显著增加 (p = 0.001).
结论:
- 环素是一种安全有效的短期治疗成人严重,耐火性亚托皮性皮炎.
- 这项研究证实了环素对患有复发性疾病的患者的治疗益处.
- 进一步的研究可能会探索长期的安全性和有效性概况.
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