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Cryopreservation of Preimplantation Embryos of Cattle, Sheep, and Goats
Published on: August 5, 2011
在胚胎移植计划中,有 amenorrhoeic 妇女的高生育率
R G Edwards1, S Morcos, M Macnamee
1Churchill College, Cambridge, UK.
Lancet (London, England)
|August 3, 1991
概括
女性生育能力随着年龄的增长而下降,但原因尚不清楚. 这项研究表明,没有定期月经周期的子宫可能会改善植入率,可能有利于不孕女性.
科学领域:
- 生殖医学 生殖医学
- 人类生育能力研究 研究人类生育能力
- 胚胎移植研究研究 胚胎移植研究
背景情况:
- 孕产妇的年龄与人类生育能力的下降有关,关于卵细胞质量或子宫内膜受体性是否是主要因素的不确定性.
- 了解与年龄相关的生育能力下降的决定因素对于开发有效的不孕症治疗至关重要.
研究的目的:
- 调查月经周期状态 ( amenorrhoeic 和 eugonadal) 对进行胚胎移植的女性的植入和怀孕率的影响.
- 确定卵细胞质量或子宫内膜受体是否是与年龄相关的植入和怀孕率下降的主要因素.
主要方法:
- 从两个胚胎移植计划 (英国和美国) 中分析植入和怀孕率.
- 根据年龄和胚胎质量分层,比较先前患有 amenorrhoeic (acyclic) 妇女和eugonadal妇女之间的比率.
- 通过捐赠者的年龄,体外胚胎生长和缺陷胚胎的比例来评估卵细胞质量.
主要成果:
- 较高的植入率和怀孕率被观察到以前有 amenorrhoeic 妇女相比 eugonadal 妇女,无论母亲的年龄或转移的胚胎的数量.
- 通过各种指标评估的卵细胞质量并没有显著影响观察到的成功率差异.
- 在治疗期间的月经周期类型没有影响结果.
结论:
- 这些发现表明,没有经历定期月经周期的子宫 (缺血状态) 可能代表着更有利的植入环境.
- 这表明子宫内膜受体性,而不是卵细胞质量,可能是与年龄相关的生育能力下降的一个更重要的因素.
- 诱导异常期可能是改善不育妇女生育结果的有益策略.
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