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Updated: Jul 10, 2026

Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage
06:51

Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage

Published on: May 6, 2020

一个高通量,高分辨率的策略,用于研究选择性DNA结合剂:分析一个"高度扭曲"的本齐米达-二胺氨酸

Kristie D Goodwin1, Mark A Lewis, Farial A Tanious

  • 1Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Purdue School of Science, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202, USA.

Journal of the American Chemical Society
|June 15, 2006
PubMed
概括

一个新的策略快速确定DNA-连接体结构. 这种方法揭示了RT29,一种胺酸-胺酸化合物,结合富含AT的DNA小槽,适应其形状以实现最佳相互作用.

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Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

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相关概念视频

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...