人类血统中的积极自然选择
P C Sabeti1, S F Schaffner, B Fry
1Broad Institute of MIT and Harvard, Cambridge, MA, USA.
概括
积极的自然选择驱动有利的特征,对人类进化至关重要. 全基因组数据现在允许识别新的选择候选人和重新评估过去的发现.
科学领域:
- 进化生物学是进化的生物学.
- 人类遗传学 人类遗传学
- 基因组学就是基因组学.
背景情况:
- 积极的自然选择增加了有利的特征,塑造了人类的进化.
- 从历史上看,人类选择研究的重点是候选基因与理论模型对比.
- 在全基因组数据的最新进展提供了新的经验方法.
研究的目的:
- 审查检测积极自然选择的方法.
- 介绍最近的全基因组选择分析的发现.
- 讨论人类基因组进化研究的未来挑战和机遇.
主要方法:
- 对全基因组序列和多形态数据的分析.
- 实证DNA序列变异与理论预期的比较.
- 在积极选择下识别新型遗传候选人.
主要成果:
- 全基因组数据可以识别新的选择候选人.
- 使用经验数据,可以对以前的选择要求进行重新评估.
- 随着大数据集的出现,新的分析方法也在出现.
结论:
- 全基因组数据彻底改变了人类自然选择的研究.
- 在人类基因组中检测积极选择变得越来越强大.
- 未来的研究将进一步阐明自然选择在人类遗传多样性中的作用.
相关概念视频
Biodiversity and Human Values
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
What is Natural Selection?
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.The Theory of Natural...
Types of Selection
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
Limits to Natural Selection
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.For one, natural selection can only act upon existing genetic variation. Hypothetically, redtusks may enhance elephant survival by deterring ivory-seeking poachers. However, if there are no gene variants—or alleles—for redtusks, natural selection cannot increase the prevalence of...
Natural Selection and Adaptation
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations, psychological...
Beyond physical adaptations, psychological...
Natural Selection and Mating Preferences
The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing, inherently...
Females, due to their biological roles in conception, pregnancy, and nursing, inherently...


