缺血性左心综合征:更多的潜在移植接受者比合适的捐赠者
A G Stuart1, C Wren, P M Sharples
1Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, UK.
Lancet (London, England)
|April 20, 1991
概括
新生儿心脏移植可以拯救患有低可塑性左心综合征的婴儿,但供体可用性非常低. 这项研究强调了婴儿心脏移植的需要和适合捐赠者的有限供应之间的巨大差距.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 移植医学 移植医学
- 新生儿手术 新生儿手术
背景情况:
- 缺血性左心综合征 (HLHS) 是一种严重的先天性心脏缺陷,需要进行干预.
- 新生儿心脏移植是一种潜在的救命治疗HLHS.
- 供体器官的可用性是新生儿移植的主要限制因素.
研究的目的:
- 评估患有HLHS的婴儿新生儿心脏移植的需要.
- 评估适合新生儿心脏移植器官捐献者的可用性.
- 为了确定实施广泛的新生儿心脏移植的障碍.
主要方法:
- 在英格兰和威尔士北部卫生区域 (1983-1990) 中对HLHS病例和潜在器官捐献者的回顾性调查.
- 对活产婴儿的分析和在子宫内诊断的HLHS.
- 审查婴儿死亡率数据,以确定潜在的捐赠者.
主要成果:
- 38名新生儿和9名胎儿在8年内发现了HLHS的病例.
- 在41名患有HLHS的活产婴儿中,有31名是潜在的移植候选人.
- 在研究期间,只有4名合适的捐赠者被确定,其中3名患有无脑症,1名头部损伤后.
- 对婴儿死亡的分析 (1987年至1989年) 从426例死亡中只产生了3个潜在的捐赠者.
结论:
- 对于HLHS的新生儿心脏移植的需求远远超过了供体可用性.
- 目前的捐赠来源不足以满足患有HLHS的婴儿的需求.
- 必须确定替代性供体来源,以扩大新生儿心脏移植在HLHS的使用.
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