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相关概念视频

Bone Remodeling01:40

Bone Remodeling

40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
What is the Skeletal System?01:02

What is the Skeletal System?

56.6K
Overview
56.6K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K

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相关实验视频

骨质疏松症是一种骨质疏松症.

Philip Sambrook1, Cyrus Cooper

  • 1Institute of Bone and Joint Research, University of Sydney, Sydney 2065, NSW, Australia. sambrook@med.usyd.edu.au

Lancet (London, England)
|June 20, 2006
PubMed
概括
此摘要是机器生成的。

骨质疏松症的管理正在推进,转向绝对骨折风险评估和更广泛地使用骨周转标记物. 双酸盐仍然是关键的,目前正在研究最佳治疗持续时间和新生物药物.

相关实验视频

科学领域:

  • 内分泌学 在内分泌学.
  • 老年学是指老年学的学科.
  • 公共卫生 公共卫生

背景情况:

  • 骨质疏松症是一个重大的全球健康问题.
  • 近年来,在了解骨质疏松症的流行病学,病理生理学和治疗方法方面取得了重大进展.
  • 持续的进步正在迅速塑造这个领域.

研究的目的:

  • 审查骨质疏松症诊断和治疗的不断变化的格局.
  • 突出临床评估和治疗策略的预期转变.

主要方法:

  • 对骨质疏松症的最新文献和临床实践趋势的审查.
  • 分析新兴的诊断工具和治疗剂.

主要成果:

  • 临床评估可能会从单独的骨密度计转向包含绝对骨折风险的算法.
  • 预计骨循环的生物化学标志物将获得更广泛的临床应用.
  • 预计双酸盐仍将是主要治疗方法,重点是优化抑制水平和治疗持续时间.

结论:

  • 未来的骨质疏松症护理可能将集成先进的风险评估工具和新的治疗选择,包括生物药物.
  • 持续的研究对于完善治疗策略和了解最佳治疗持续时间和强度至关重要.