金 (((I) 催化合成的二甲
Benjamin D Sherry1, Lisa Maus, Brian Ngo Laforteza
1Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720, USA.
Journal of the American Chemical Society
|June 22, 2006
概括
一个金 ((I) -oxo复合物催化了从propargyl乙烯基乙烯中控制的二基和螺旋的合成. 黄金催化剂能够实现出色的二重选择性和性转移,有效地创建复杂的循环结构.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 黄金化学 黄金化学
背景情况:
- 在有机合成中,propargyl 乙烯基乙是多功能前体.
- 含氧异环的立体控制合成仍然是一个关键的挑战.
- 黄金催化已经成为复杂分子构建的强大工具.
研究的目的:
- 开发一种新的黄金-氧复合物,作为有机转换的催化剂.
- 为了研究2 - 基-3,6-二皮兰的立体控制合成.
- 探索催化剂在构建螺旋体框架中的实用性.
主要方法:
- 使用三核黄金(I) -oxo复合物,[(Ph3PAu) 3O]BF4,作为催化剂.
- 在重新排列反应中使用propargy vinyl ethers作为基质.
- 使用分析技术,分析反应产品的立体选择性和性转移.
主要成果:
- 黄金催化剂促进了具有高 diastereoselectivity 的 2-基-3,6-二基的立体控制合成.
- 基拉尔非血红性propargyl乙烯乙烯经过了以优异的基拉性转移进行重新排列,产生了富含enantio的piran.
- 该反应成功地应用于从线性前体合成双循环螺旋的单个步骤,在三个中心进行完整的立体控制.
结论:
- 三核黄金 ((I) -oxo复合物是二和螺旋的立体选择性合成的有效催化剂.
- 该方法为构建复杂的性氧化异环提供了一个强大的途径.
- 这种催化系统为有价值的分子架构提供了高效和立体控制的方法.
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