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在幼儿中意外的阿斯泰米尔过量服用
K Hoppu1, T Tikanoja, P Tapanainen
1Children's Hospital, 2nd Department of Paediatrics, Helsinki, Finland.
Lancet (London, England)
|August 31, 1991
概括
在幼儿中,意外的阿斯泰米醇中毒会导致危险的心律问题. 仔细的医院监测对于过量服用阿斯泰米的儿科患者至关重要,特别是那些服用其他H1抗组胺药物的儿科患者.
科学领域:
- 儿科毒理学 儿科毒理学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿斯泰米醇是一种选择性的H1-胺受体对抗剂.
- 在幼儿中意外过量服用可能导致显著的毒性.
- 心脏不良事件是抗组胺剂量过量的担忧.
研究的目的:
- 报告小孩意外中毒的astemizole病例.
- 描述astemizole过量服用的临床表现和心脏影响.
- 建议对儿科阿斯泰米醇中毒进行适当的治疗.
主要方法:
- 从国家中毒控制中心报告的回顾性案例系列.
- 对患者人口统计,摄入剂量和临床结果的分析.
- 电心电图 (ECG) 监测心脏毒性,包括QTc间隔.
- 在特定情况下测量药物度.
主要成果:
- 在1岁7个月至3岁4个月的儿童中,有6例意外的阿斯蒂米过量服用.
- 摄入剂量在2.5至16.7毫克/公斤之间,明显超过推水平.
- 在所有5名可用心电图的儿童中观察到延长的QTc间隔 (心脏毒性标志).
- 在1名儿童中发展出严重的心室节律失常.
结论:
- 意外过量服用阿斯泰米的幼儿需要在医院进行仔细的监测.
- 心脏毒性,包括QTc延长和心律失常,是显著的风险.
- 对于其他选择性H1-胺受体对抗剂的过量服用,可能需要进行类似的监测.
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