A型流感和脑膜炎球菌病
K A Cartwright1, D M Jones, A J Smith
1Public Health Laboratory, Gloucester Royal Hospital, UK.
Lancet (London, England)
|August 31, 1991
概括
流感A疫情可能会增加脑膜炎球菌疾病的风险. 这项研究发现了显著的关联,表明甲型流感抑制免疫力,使个人更容易受到脑膜炎球菌感染的影响.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 事证据表明,流感和脑膜炎球菌病爆发之间存在联系.
- 1989年底在英格兰和威尔士的一次流感A爆发后,脑膜炎球菌感染的显著增加.
研究的目的:
- 调查甲型流感疫情与随后脑膜炎球菌病发病率之间的关系.
- 为了量化A型流感流行后发生脑膜炎球菌病的风险.
主要方法:
- 病例控制研究设计,将脑膜炎球菌病患者与年龄相匹配的对照进行比较.
- 血清检测检测研究参与者最近的流感A感染.
主要成果:
- 患有脑膜炎球菌病的患者显著更有可能有最近流感A感染的血清学证据 (OR=3.9,95% CI 1.2-13.9).
- 这种联系在A型流感爆发后大约两周后被观察到.
结论:
- 流感A型感染似乎增加了对脑膜炎球菌疾病的易感性,可能是由于诱导免疫抑制.
- 公共卫生策略应考虑这一关联,为流感A流行期间脑膜炎球菌疾病风险增加做好准备.
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