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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
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在新皮层中,经验依赖和细胞类型特定的脊柱生长.

Anthony Holtmaat1, Linda Wilbrecht, Graham W Knott

  • 1Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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概括
此摘要是机器生成的。

新的感官体验稳定了成人新皮质中的新树突,增强了突触连接. 这个过程重塑神经回路,特别是在5B层的金字塔神经元中,有助于大脑的可塑性.

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科学领域:

  • 神经科学是一个神经科学.
  • 突触性可塑性 突触性可塑性
  • 皮层电路的皮层电路.

背景情况:

  • 成人的新皮质回路适应新的感官信息.
  • 驱动这种适应的特定突触机制,例如树突性脊柱动力学,尚未完全理解.
  • 大多数激发性突触的部位 - - 状,其大小和稳定性各不相同,影响神经元激发.

研究的目的:

  • 调查是否新的感官体验增强了持续的树突状棘的形成和消除.
  • 为了确定由感官体验诱导的脊柱变化的突触后果.
  • 确定表现出经验依赖脊柱稳定性的神经元子类.

主要方法:

  • 在一个月的时间里,在老鼠皮层中重复的树突棘体内成像.
  • 通过修剪交替的胡须来诱导新的感官体验.
  • 在5B层金字塔神经元上分析脊柱形成,消除和突触形成.

主要成果:

  • 胡须修剪稳定了新形成的树突棘,并破坏了现有的持久棘的稳定.
  • 新稳定的脊柱始终形成突触.
  • 脊柱稳定主要发生在具有复杂顶端的5B层神经元上.
  • 短暂的棘通常很小,而持久的棘更大.

结论:

  • 新的感官体验促进了特定皮层神经元子类中的新树突脊柱的稳定.
  • 这些经验驱动的突触修饰对于新皮质回路的重塑至关重要.
  • 这些发现阐明了一个关键的突触机制,它是经验依赖的大脑可塑性的基础.