在阴道静脉血栓症中用肝素治疗
K M Einhäupl1, A Villringer, W Meister
1Department of Neurology, Ludwig-Maximilians-Universität München, Germany.
Lancet (London, England)
|September 7, 1991
概括
治疗阴道静脉血栓 (SVT) 的肝素治疗改善了患者的治疗结果. 这项研究发现,与安慰剂相比,肝素显著降低了缺陷和死亡率,即使是内出血 (ICH).
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 血栓形成研究研究
背景情况:
- 阴道静脉血栓症 (SVT) 治疗是有争议的,由于内出血 (ICH) 风险,人们对肝素的使用存在担忧.
- 以前的方法缺乏关于肝素在SVT患者的疗效和安全性的确切证据.
研究的目的:
- 为了评估抗凝剂的有效性,调整剂量静脉注射肝素用于无菌性SVT.
- 为了确定ICH是否是SVT患者肝素治疗的禁忌.
主要方法:
- 一个随机的,盲目的,安慰剂控制的研究,涉及20名无菌性SVT患者 (10赫巴林,10安慰剂).
- 对102名SVT患者进行了回顾性分析,其中包括43名ICH患者,以评估肝素对结果的影响.
- 使用SVT严重程度尺度进行临床过程评估,并修改费舍尔精确测试进行统计分析.
主要成果:
- 与安慰剂 (p<0.05) 相比,从第三天开始,肝素组的临床结果显著改善 (p<0.05).
- 3个月后,80%的肝素治疗患者完全康复或出现轻微缺陷,而安慰剂组只有10% (p<0.01).
- 在追溯的ICH队列中,肝素治疗与较低的死亡率 (15% vs. 69%) 和较高的康复率相比,没有肝素.
结论:
- 调整剂量的静脉注射肝素是SVT的有效治疗方法.
- 在SVT患者中,内出血 (ICH) 不是对肝素治疗的禁忌.
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