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在BEAM疗法后,转基因-CSF代替了自身骨髓移植

J P Laporte¹, L Fouillard, L Douay

¹Bone Marrow Transplant Unit, Hopital St Antoine, Paris, France.

Lancet (London, England)

|September 7, 1991

概括

颗粒细胞巨细胞殖民地刺激因子 (GM-CSF) 在自身骨髓移植无法实现时,在耐药非霍奇金淋巴瘤 (NHL) 患者中表现有前途. 这种疗法在一些患者中促进了造血的恢复,表明作为替代治疗的潜力.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

非霍奇金淋巴瘤 (NHL) 可能对标准治疗不耐药.
自主骨髓移植 (BMT) 是一种常见的巩固疗法.
淋巴瘤细胞持续透骨髓可以排除BMT.

研究的目的:

评估颗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 在耐药NHL患者的疗效.
为了评估GM-CSF作为一种潜在的替代品自主 BMT 当骨髓参与存在时.

主要方法:

五名耐药NHL患者接受了GM-CSF (每天250微克/平方米) 的BEAM后化疗.
BEAM治疗方案包括卡慕斯,埃托波西德,细胞氨酸和梅尔法兰.
当持续的淋巴瘤细胞透阻止了自身的 BMT 时,就进行了治疗.

主要成果:

五分之三的患者实现了完全的造血复合.
造血复原动力学与自性BMT后观察到的动力学相似.
两名患者无法实现持续的造血复苏,并死亡.

结论:

在精选的NHL患者中,GM-CSF可能会成为自主BMT的可行替代品.
这种方法特别适用于疾病进展和骨髓干扰的病例.
需要对高度精选的患者队伍进行进一步的研究.

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