门癌和子宫癌之间存在病因相似之处
1Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Lancet (London, England)
|September 14, 1991
概括
门癌与子宫癌具有强烈的风险因素. 患有宫内皮质瘤 (CIN) 或侵袭性宫癌史的女性患癌的可能性明显更高.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 妇科 妇科医生 妇科
背景情况:
- 癌的病因被认为涉及传染病或性行为,类似于宫癌.
- 以前的宫内皮质瘤 (CIN) 或侵袭性宫癌的诊断是癌的潜在风险因素.
研究的目的:
- 调查宫内皮质瘤 (CIN) 或侵袭性宫癌的病史与患癌的风险之间的关联.
- 为了比较门癌与其他癌症 (如结肠癌,胃癌和癌) 的风险,与宫异常相关.
主要方法:
- 一项涉及29,648名妇女的病例控制研究,这些妇女在1968年至1987年期间在丹麦癌症登记处注册了癌症.
- 对先前的CIN或侵袭性宫癌的几率比率的分析在门癌患者与结肠癌,胃癌或癌患者之间.
- 从CIN诊断到注册癌症诊断的中位时间的计算.
主要成果:
- 与结肠癌 (OR 5.2) 和胃癌 (OR 3.6) 患者相比,癌患者患有CIN的可能性显著更高.
- 与癌相比,癌和CIN之间的关联也被观察到,尽管明显程度较低 (OR 1.6).
- 门癌症患者也比部癌症患者更有可能患有侵入性宫癌 (OR 1.8).
结论:
- 门癌与CIN或侵袭性宫癌史之间存在强烈的关联,这表明有共同的风险因素.
- 鉴定出癌的风险因素似乎与癌相比,至少与癌的风险因素一样强大.
- 这些发现支持了传染病原体和/或性行为在癌的病因学中起作用的假设.
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