中性粒细胞亡和新生儿肺部的清除
J M Grigg1, J S Savill, C Sarraf
1Department of Paediatrics, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Lancet (London, England)
|September 21, 1991
概括
在新生儿有呼吸道炎症时观察到中性粒细胞亡和巨细胞摄入. 这一过程可以减少新生儿肺炎炎症的缓解过程中的组织损伤.
科学领域:
- 新生儿免疫学 新生儿免疫学
- 肺部医学 肺部医学
- 细胞生物学 细胞生物学
背景情况:
- 新生儿肺炎是一个重要的临床问题.
- 解决炎症对于预防长期肺损伤至关重要.
- 了解中性粒细胞的行为是管理新生儿呼吸道炎症的关键.
研究的目的:
- 为了研究机械通风的新生儿的气道中中性粒细胞的命运,有炎症.
- 探索中性粒细胞清除的机制及其在炎症解决中的作用.
主要方法:
- 支气管支气管洗对8名呼吸道炎症的新生儿进行了.
- 光显微镜和电子显微镜被用来分析中性粒细胞亡和巨细胞灭菌.
主要成果:
- 在所有8名婴儿中都发现了中性粒细胞亡的证据.
- 在所有标本中观察到巨细胞摄入完整的中性粒细胞.
- 没有注意到从亡性中性粒细胞中显著释放的促炎性细胞内含量.
结论:
- 中性细胞亡和随后的巨细胞灭是解决新生儿肺炎的关键事件.
- 这种机制可以通过防止炎症媒介的释放来限制组织损伤.
- 这些发现表明,中性粒细胞亡在新生儿肺炎中起着保护作用.
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