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在V(D) J重组过程中,ATM稳定了DNA双链断裂复合体

Andrea L Bredemeyer1, Girdhar G Sharma, Ching-Yu Huang

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Nature
|June 27, 2006
PubMed
概括

突变的阿塔克西亚-泰朗基切塔西亚 (ATM) 蛋白激酶对于DNA修复和细胞对DNA双链断裂 (DSB) 的反应至关重要. 缺少ATM会损害DNA修复,增加癌症风险,特别是淋巴细胞恶性瘤.

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