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白天血压模式和充血性心力衰竭的风险
Erik Ingelsson1, Kristina Björklund-Bodegård, Lars Lind
1Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. erik.ingelsson@pubcare.uu.se
JAMA
|June 29, 2006
概括
夜间血压模式,特别是"不滴血",显著预测老年男性的充血性心力衰竭 (CHF) 风险. 这一发现为预防心血管疾病提供了超越传统血压测量的新见解.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 预防医学 预防医学
背景情况:
- 高血压是充血性心力衰竭 (CHF) 的主要危险因素.
- 改变白天血压模式对后续心血管疾病风险的影响尚不清楚.
研究的目的:
- 为了评估24小时的门诊血压特征作为CHF发病率的预测指标.
- 为了确定改变的白天血压模式是否提供了传统办公室测量之外的额外风险信息.
主要方法:
- 一项前性,基于社区的观察性队列研究,对951名在基线没有心血管衰竭的老年男性进行了研究.
- 在基线时进行的24小时门诊血压监测.
- 分析血压变量作为随后的CHF住院预测因素.
主要成果:
- 夜间透析血压 (HR,1.26) 和"不下降"血压 (HR,2.29) 的1-SD升高与心血管衰竭风险增加有关.
- 即使调整为办公室血压测量 (HR,2.21) 之后",不滴滴"仍然是一个显著的预测因素.
- 在排除患有心肌梗塞的参与者之后,这些关联仍然存在.
结论:
- 夜间血压模式,特别是"不滴滴",为心血管衰竭提供了重要的风险信息.
- 这些信息与传统的办公室血压读数和已确定的风险因素相比是增量.
- 需要进一步的研究来确定这些发现的临床实用性.
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