抗生素耐药性在Mycobacterium结核病的竞争性成本
Sebastien Gagneux1, Clara Davis Long, Peter M Small
1Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA. sgagneux@systemsbiology.org
Science (New York, N.Y.)
|July 1, 2006
概括
耐多药结核菌株可以在没有健康成本的情况下出现,挑战流行病预测. 特定的突变和宿主遗传学会影响Mycobacterium tuberculosis的耐药性成本.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 数学模型表明,多抗药结核病 (MDR-TB) 的未来取决于耐药性的健身成本.
- 了解这种健康成本对于预测和控制MDR-TB流行病至关重要.
研究的目的:
- 调查耐药性突变与Mycobacterium结核病的健康成本之间的关系.
- 确定临床MDR-TB分离物是否表现出与耐药性相关的适应性缺陷.
主要方法:
- 实验室衍生了Mycobacterium结核病突变菌与里法抗药性.
- 竞争性健康测试比较耐药和易感菌株.
- 在实验室和临床隔离物中分析耐药性突变和遗传背景.
主要成果:
- 实验室突变物中的利法抗性始终与具有竞争力的健身成本有关.
- 这种健康成本的规模取决于特定的耐药性突变和Mycobacterium结核病菌株的遗传背景.
- 长时间的患者治疗可能会导致没有明显的健康缺陷的MDR-TB菌株.
- 临床分离物经常存在低成本或无成本的抗性突变,这表明它们的进化优势.
结论:
- 与一些预测相反,Mycobacterium结核病的耐药性并不总是会给人带来健康成本.
- 耐药性结核病的演变受到特定突变和宿主因素的影响,这些因素可以最大限度地减少或消除健康处罚.
- 在临床环境中,低成本或无成本的耐药性突变的流行程度突显了它们在持续的MDR-TB流行病中的重要作用.
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