用于治疗神经系统疾病的干细胞
1Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, SE-221 84 Lund, Sweden. olle.lindvall@med.lu.se
Nature
|July 1, 2006
概括
研究人员正在开发干细胞疗法,以再生神经元和神经质细胞在帕金森病等神经系统疾病中丢失. 现在的重点是将这些实验室发现转化为患者的临床治疗.
科学领域:
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
- 干细胞生物学 干细胞生物学
背景情况:
- 神经系统疾病,包括帕金森病,中风和多发性硬化症,以神经元和质细胞损失为特征.
- 干细胞研究已经成功地在培养中产生神经元和质细胞,为移植疗法铺平了道路.
- 最近的进展包括刺激成人中枢神经系统内源性干细胞,以促进神经元和质细胞的形成和存活.
研究的目的:
- 总结基于干细胞治疗神经系统疾病的进展情况.
- 要突出转向刺激内源性干细胞修复在中枢神经系统的转变.
- 强调实验室研究和临床应用之间的翻译差距.
主要方法:
- 在神经退行性疾病模型中对最近的干细胞研究进行审查.
- 对体内神经发生和脑细胞发生的策略的分析.
- 讨论将干细胞疗法转化为临床实践的挑战.
主要成果:
- 在实验室中从干细胞中成功生成神经元和质细胞.
- 开发激发中枢神经系统内源干细胞修复的方法.
- 确定临床翻译的关键挑战.
结论:
- 基于干细胞的方法在治疗神经系统疾病方面显著有前途.
- 刺激内源性修复是一种有前途的治疗途径.
- 弥合临床前研究和临床应用之间的差距是开发有效疗法的关键下一步.
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