口服苏马特里普坦在急性偏头痛中使用
P J Goadsby1, A S Zagami, G A Donnan
1Department of Neurology, Prince Henry, Australia.
Lancet (London, England)
|September 28, 1991
概括
口服苏马特里普坦有效治疗急性偏头痛发作. 这项研究发现,与安慰剂相比,苏马特里普坦显著降低了偏头痛的严重程度,副作用最小.
科学领域:
- 神经学 神经学
- 临床药理学 临床药理学
背景情况:
- 偏头痛是一种常见的神经疾病.
- 有效的急性治疗对于管理偏头痛发作至关重要.
研究的目的:
- 评估口服苏马特里普坦治疗急性偏头痛的疗效和耐受性.
- 为了在受控环境中比较sumatriptan与安慰剂的有效性.
主要方法:
- 这是一项双盲,随机,安慰剂控制,交叉研究.
- 包括61名患有急性偏头痛的患者.
- 患者在四次发作中接受了100毫克苏马特里普坦或安慰剂.
主要成果:
- 苏马特利普坦在2小时内显示出显著更高的响应率 (51%) 与安慰剂 (10%) 相比 (p<0.01).
- 较少的患者需要在2小时后使用苏马特里普坦 (41%) 和安慰剂 (88%) 的救援药物.
- 没有报告任何显著的副作用.
结论:
- 口服苏马特里普坦是治疗急性偏头痛的有效和耐受性良好的治疗方法.
- 苏马特里普坦为偏头痛患者提供了一种有价值的治疗选择.
- 进一步的研究可以探索长期疗效和复发模式.
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