内动脉脉脉动率指数与皮肤间的雌激素和绝经以来的时间有关
K F Gangar1, S Vyas, M Whitehead
1Academic Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London, UK.
Lancet (London, England)
|October 5, 1991
概括
绝经后的雌激素治疗可以通过影响动脉度来改善心血管健康. 透皮雌激素降低了女性的脉动性指数 (PI),这表明除了脂蛋白之外的一般性动脉效应.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 血管生物学 血管生物学
背景情况:
- 从绝经后雌激素替代的心血管疾病保护并不能完全由脂蛋白变化解释.
- 通过雌激素调节动脉调,需要在绝经后妇女中进一步研究.
研究的目的:
- 为了研究透皮雌激素对绝经后妇女动脉度的影响.
- 评估内动脉血液流动特征的变化.
主要方法:
- 用多普勒超声波测量了12名绝经后妇女的内动脉脉脉动率指数 (PI).
- 患者接受了22周的透皮雌激素 (50微克/天),在基线和第4,6,9和22周进行测量.
- 分析了绝经后的时间和PI之间的相关性,以及治疗期间PI的变化.
主要成果:
- 在绝经后的时间和基线PI (r=0.77) 之间发现了显著的相关性.
- 通过皮肤给予的雌激素治疗导致PI变化和PI平均值 (r=-0.70) 之间存在显著的负相关性.
- 更年期以来的较长时间与雌激素治疗期间PI的较大降低相关.
结论:
- 雌激素治疗似乎对动脉系统有普遍的影响,影响动脉度.
- 这些发现表明,除了脂蛋白修饰之外,雌激素的心血管保护机制存在.
- 降低PI表明血液流动阻抗降低,可能改善动脉循环.
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