抗血素III和动脉疾病
T W Meade1, J Cooper, G J Miller
1MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, UK.
Lancet (London, England)
|October 5, 1991
概括
低和高的抗血素III水平都会增加动脉疾病的风险. 这项前性研究发现,与中等水平相比,抗血素III水平极高的男性患有动脉疾病的死亡率更高.
科学领域:
- 心血管科学 心血管科学
- 血液学 血液学 血液学
背景情况:
- 截面研究表明,抗血素III水平与动脉疾病风险之间存在联系.
- 低和高的抗素III水平都与增加的风险有关,特别是缺血性心脏病 (IHD).
研究的目的:
- 为了前性地研究抗素III水平与随后死于动脉疾病之间的关系.
主要方法:
- 诺斯威克公园心脏研究对893名男性进行了前性分析.
- 评估了抗素III水平,并与因子VII活性和血纤维素原水平相关联.
主要成果:
- 观察到抗血素III水平与较高的因子VII活性和血纤维素原之间存在直接相关性.
- 与中间三分之一相比,抗血素III分布的最低和最高三分之一的动脉疾病死亡率更高.
结论:
- 极低和极高的抗血素III水平都与动脉疾病死亡风险增加有关.
- 这些发现强调了抗血素III水平和动脉疾病死亡率之间的潜在U形关系.
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