在用天然β干扰素治疗后,急性型肝炎的消失
M Omata1, O Yokosuka, S Takano
11st Department of Medicine, Chiba University School of Medicine, Japan.
Lancet (London, England)
|October 12, 1991
概括
在一项受控试验中,干扰素治疗有效地预防了慢性型肝炎的进展. 大多数接受治疗的患者获得了正常的肝酶和无法检测到的HCVRNA,这表明干扰素可以消除病毒.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 急性非A,非B型肝炎,现在称为C型肝炎,可导致慢性肝病.
- 预防慢性病的有效治疗对于患者的治疗结果至关重要.
研究的目的:
- 评估干扰素在预防急性非A,非B型肝炎向慢性疾病进展方面的疗效.
- 为了确定干扰素是否可以根除C型肝炎病毒 (HCV).
主要方法:
- 一项前性受控试验,涉及25名患有急性非A,非B型肝炎的患者.
- 11名患者接受了干扰素治疗 (平均30天,52兆单位),而14人作为对照.
- 随访包括3年的血清氨基转移酶水平和HCVRNA检测.
主要成果:
- 91%的治疗患者在3年后将血清氨基转移酶水平正常化,而对照组的25% (p<0.02).
- 在11名治疗患者中,HCVRNA在10名患者中变得无法检测,而在12名对照组中只有1名患者.
- 给4名患有持续升高的氨基转移酶水平的患者进行了第二次干扰素疗程.
结论:
- 干扰素治疗有效防止急性非A,非B型肝炎向慢性感染的进展.
- 干扰素治疗似乎可以根除HCV,从而导致持续的生化和病毒学缓解.
- 使用干扰素的早期干预对治疗型肝炎具有显著的前景.
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