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在被二氧化污染的化学工厂的工人中,癌症死亡率
1Centre for Chemical Workers' Health, Department of Health, Hamburg, Germany.
Lancet (London, England)
|October 19, 1991
概括
这项研究跟踪了暴露于二氧化物 (2,3,7,8-四二子-p-二氧化物或TCDD) 的除草剂工厂工人. 结果表明TCDD暴露与男性癌症死亡率增加和女性乳腺癌增加有关,支持其致癌性.
科学领域:
- 职业健康 职业健康 职业健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 素 (2,3,7,8-四二子-p-素或TCDD) 是除草剂生产中的一种污染物.
- 众所周知,TCDD会引起,但其对人类的致癌性仍在争论中.
研究的目的:
- 为了调查德国一家除草剂生产工厂中暴露于TCDD的工人的死亡模式.
- 评估该队列中TCDD暴露与癌症死亡率之间的关联.
主要方法:
- 一项对1583名工人 (1952-1984) 进行的死亡随访研究,他们的生命状况在1989年之前被确定.
- 总癌症和特定癌症的标准化死亡率 (SMR) 的计算,与国家统计数据和天然气工人队列进行比较.
- 根据就业时间,开始日期和可疑的TCDD暴露水平分层分析.
主要成果:
- 在男性中,总体癌症死亡率较高 (SMR 1.24-1.39).
- 在长时间就业,早期就业日期和高TCDD暴露的男性中观察到癌症死亡率增加.
- 在女性中,乳腺癌死亡率升高 (SRM = 2.15),但整体癌症风险没有增加.
结论:
- 这些发现支持TCDD是人类致癌物的假设.
- 在除草剂生产中对TCDD的职业暴露与男性的癌症风险增加和女性的乳腺癌风险增加有关.
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