在印度尼西亚用Ty21a疫苗对伤寒的口服免疫
C H Simanjuntak1, F P Paleologo, N H Punjabi
1Center for Infectious Diseases Research, National Institutes of Health Research and Development, Jakarta, Indonesia.
Lancet (London, England)
|October 26, 1991
概括
在印度尼西亚,口服的伤寒疫苗Ty21a显示出对伤寒的保护性有效性. 液体配方提供了53%的保护,肠膜囊提供了42%的保护.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 伤寒热仍然是一个重要的全球健康问题,特别是在传播率高的地区.
- 之前的研究表明,口服伤寒疫苗Ty21a在不同环境下具有不同的疗效.
- 了解在强烈传播下疫苗的性能对于公共卫生战略至关重要.
研究的目的:
- 在强烈的伤寒传染条件下,比较两种口服伤寒疫苗Ty21a (液体和肠膜囊) 配方在强烈的伤寒传染条件下的疗效.
- 评估Ty21a在高风险人群中对沙门氏菌Typhi感染的保护作用.
主要方法:
- 在印度尼西亚进行了一项随机双盲试验,涉及20543名年龄在3-44岁之间的参与者.
- 参与者接受了三剂Ty21a或安慰剂,以液体或肠膜囊形式.
- 血培阳性伤寒热的随访发生在30个月内.
主要成果:
- 在对照组中,伤寒发烧的发病率为每10万人/年中有810.
- 液体配方Ty21a的保护效率为53%,而肠膜囊的保护效率为42%.
- 两种疫苗配方都没有提供对沙门氏甲状病毒感染的保护,并且疫苗组报告的副作用发生率更高.
结论:
- 口服的伤寒疫苗Ty21a即使在强烈的传播条件下,也能对伤寒产生保护作用.
- 在这种情况下,液体配方似乎比肠膜囊更有效.
- 鉴于保护不完整,需要采取额外的疾病预防策略.
关键词:
年龄因素 年龄因素亚洲 亚洲 亚洲 亚洲细菌和真菌疾病 - - 预防和控制生物学 生物学 生物学临床研究 临床研究控制小组 控制小组提供医疗保健服务.人口结构因素 人口结构因素发展中国家 发展中国家疾病 疾病 疾病双盲研究 双盲研究评价 评价 评价卫生健康 卫生健康 卫生健康卫生服务 卫生服务 卫生服务豁免权是一种豁免权.免疫接种 免疫接种事件发生率 事件发生率印度尼西亚 印度尼西亚 印度尼西亚感染 感染 感染测量方法 测量方法生理学 生理学 生理学人口人口的人口人口.人口特征 人口特征初级医疗保健是一项主要的医疗保健.研究方法研究方法研究方法学东南亚的东南亚地区.研究研究研究研究研究研究.接种疫苗 - 副作用疫苗 - - 管理和剂量.更多相关视频
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