没有心心的生活:眼在聚光灯下
Jose L Badano1, Nicholas Katsanis
1McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Cell
|July 4, 2006
概括
中心对于乳毛形成至关重要. 果缺少中心细胞会正常发育,但由于有缺陷的感觉神经元而过早死亡,这凸显了在感觉功能中的关键作用.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 神经科学是一个神经科学.
背景情况:
- 中心体是中心体和基底体的核心结构组成部分.
- 基底体对于乳毛的核和组装至关重要.
- 乳毛在细胞结构和功能中起着至关重要的作用,在各种各样的生物体中发挥作用.
研究的目的:
- 为了研究中心在果发育和生存中的作用.
- 为了确定成熟生物体中中心离子缺失的具体后果.
- 为了阐明感官神经元中纤毛的必要性.
主要方法:
- 基因操纵以创建没有中心点的果突变种.
- 观察发育进展和寿命.
- 分析感官神经元的结构和功能.
主要成果:
- 果缺乏中心球可以达到成年期.
- 中心的缺失导致感觉神经元中的毛损失.
- 在感觉神经元中缺乏功能性乳头会导致过早死亡.
结论:
- 中心对于果最初的发展来说并不重要.
- 中心对于功能性感官毛的形成是不可或缺的.
- 由于中心球损失而缺少感官,在成年果中是致命的.
相关概念视频
Microtubules in Cell Motility
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Microtubules in Signaling
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Centrioles and Centrosomes
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...
Near the end of the prophase, also called late prophase or "prometaphase,"...
Microtubules in Cell Motility
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...


