极度肥胖妇女的死亡率和心脏和血管结果
Kathleen McTigue1, Joseph C Larson, Alice Valoski
1Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pa 15213, USA. mctiguem@.edu
JAMA
|July 6, 2006
概括
极度肥胖会显著增加女性的心血管和死亡风险,风险在体重类别中升级. 这些风险往往是由糖尿病和高血压等疾病介导的.
科学领域:
- 心血管健康 心血管健康
- 肥胖问题研究研究
- 流行病学 流行病学
背景情况:
- 肥胖症被定义为身体质量指数 (BMI) 30或以上,被分为肥胖症1 (30-34.9),肥胖症2 (35-39.9) 和极度肥胖症 (≥40).
- 极端肥胖症在美国迅速增加,但与之相关的健康风险需要进一步描述.
研究的目的:
- 调查女性不同临床体重类别中心血管和死亡风险的差异.
- 特别关注与极度肥胖相关的健康风险.
主要方法:
- 从妇女健康倡议观察研究中分析了90,185名妇女的事件死亡率和心血管结果.
- 随访持续时间平均为7.0年,数据收集时间为1993年10月1日至2004年8月31日.
- 结果包括死亡率,冠心病,糖尿病和高血压发病率.
主要成果:
- 每1万人/年的全因死亡率随着体重类别的增加而增加,从正常的BMI到极度肥胖.
- 经过调整后的分析表明,与体重相关的死亡率和冠心病风险在种族/种族之间没有差异.
- 发现糖尿病,高血压和高脂血症调解了与肥胖相关的死亡率和冠心病风险的很大一部分.
结论:
- 仅将肥胖定义为BMI为30或更高,可能导致对个人和人口健康风险的误解.
- 极度肥胖的增加可能会加剧正在进行的肥胖流行病的健康影响和相关成本.
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