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相关概念视频

RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...
The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

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相关实验视频

Updated: May 7, 2026

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

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Published on: June 21, 2016

对于v-ErbA来说,一种新的作用机制:通过视网酸和甲状腺激素受体取消转录因子AP-1的失活.

C Desbois1, D Aubert, C Legrand

  • 1Immuno-Virologie Moléculaire et Cellulaire Université Claude Bernard Lyon-1/CNRS UMR30, Faculté de Médecine Alexis Carrel, Lyon, France.

Cell
|November 15, 1991
PubMed
概括

视网酸受体α (RARα) 和c-ErbAα抑制了AP-1的活性,而v-ErbAcoprotein则破坏了这种抑制. 这种v-ErbA的作用促进细胞生长,可能有助于癌症的发展.

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相关实验视频

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Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

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Published on: June 21, 2016

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

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科学领域:

  • 分子生物学分子生物学
  • 在瘤学瘤学.
  • 基因法规 基因法规

背景情况:

  • 已知网红酸受体α (RARα) 和c-ErbAα抑制AP-1的转录活性.
  • AP-1转录因子在调节参与细胞增殖和分化的基因中起着至关重要的作用.

研究的目的:

  • 研究v-ErbAcoprotein与AP-1转录因子相互作用的机制.
  • 阐明v-ErbA在克服RARα和c-ErbAα对AP-1活性抑制作用中的作用.
  • 为了将v-ErbA对AP-1的影响与其致癌潜力以及对细胞对视网酸反应的影响相关联.

主要方法:

  • 对间歇性原酶基因促进体的AP-1介导的转录激活的分析.
  • 在RARα,c-ErbAα和v-ErbA的存在下评估AP-1转录因子的活性.
  • 在v-ErbA表达的背景下,对胚胎纤维细胞对视网酸治疗的增长抑制反应的评估.

主要成果:

  • 经证实,体激活的RARα和c-ErbAα可以抑制AP-1的活性.
  • 这种v-ErbA基蛋白未能抑制AP-1的活性,并且作为一种主导的负子,克服了RARα和c-ErbAαα的抑制.
  • v-ErbA保持了完全活跃的AP-1复合体,这与酸对纤维细胞增长抑制作用的废除相关.

结论:

  • 在AP-1上,v-ErbA破坏了RARα和c-ErbAα的正常调节功能.
  • 这种v-ErbA对AP-1调节的干扰有助于不受控制的细胞增殖.
  • 这些发现表明v-ErbA的致癌活性存在一种新的机制,这可能解释了它在瘤发生和白血病发生中的作用.