活着的自主心脏门是从人类产前采集的祖先中设计的
Dörthe Schmidt1, Anita Mol, Christian Breymann
1Clinic for Cardiovascular Surgery and Department of Surgical Research, University and University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland.
Circulation
|July 6, 2006
概括
这项研究使用产前前细胞设计了活体心脏门传单,为新生儿创建了自主植入物. 这种新的方法为未来的增长和产后应用通过细胞银行提供了潜力.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 发展生物学 发展生物学
背景情况:
- 心脏膜组织工程旨在为先天性形创造生长的,自主替代的替代物.
- 来自人类产前前代细胞的新型细胞源被探索用于生成特定患者的植入物.
- 这种方法旨在提供出生时可用的功能性心脏门置换.
研究的目的:
- 通过使用人类产前前代细胞,设计活心的传单.
- 评估使用这些工程组织作为新生儿自身植入物的可行性.
- 评估这种组织工程结构的生长潜力和产后应用.
主要方法:
- 人类胎儿中细胞的祖先从胆毛样本中分离出来并扩展.
- 细胞被播种在可生物降解的支架上,在生物反应堆中培养,并内皮化.
- 对工程组织进行了细胞表型,细胞外基质,机械性能和表面特征的分析.
主要成果:
- 产前的祖先在扩张和冷保存后保持了肌纤维细胞类型的表型.
- 工程心脏门小册子展示了与本地组织相比较的组织,细胞外基质和DNA含量.
- 功能性内皮覆盖了小册子表面,机械型号近似了原生门功能.
结论:
- 产前胎儿前代是设计活体心脏门传单的可行的细胞来源.
- 这种方法可以创建自主,生长潜力的植入物,准备在出生时使用.
- 细胞银行技术可以将这种方法扩展到产后应用.
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