自主的人体组织工程心脏门:系统应用的前景
Anita Mol1, Marcel C M Rutten, Niels J B Driessen
1Clinic for Cardiovascular Surgery, University Hospital Zürich, Zürich, Switzerland. a.mol@tue.nl
Circulation
|July 6, 2006
概括
这项研究开发了组织工程的人类心脏门,使用沙静脉细胞和合成脚手架. 这些活体的大动脉置换显示出有前途的组织特性和机械行为,可用于未来的临床应用.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 心血管研究研究心血管研究
背景情况:
- 组织工程为创造活体心脏门置换提供了一个有希望的解决方案.
- 目前的研究主要集中在动物模型中的肺门置换.
- 开发组织工程心脏门用于人类细胞的系统性使用仍然是一个重大挑战.
研究的目的:
- 使用人类细胞创建自主组织工程心脏门,用于潜在的大动脉门置换.
- 评估生物反应器调节对组织发育和机械性能的影响.
- 在生理流量条件下评估工程门的功能性能.
主要方法:
- 利用了人类的静脉细胞,播种在快速降解的合成支架上.
- 静态培养和动态生物反应器调节之间的组织发育和机械性能比较.
- 将工程门暴露在模拟生理性大动脉门流动中,以评估传单运动.
主要成果:
- 组织形成和机械性能在4周的培养过程中得到改善,特别是在生物反应器条件下.
- 动态调节增强了组织组织和异型特性.
- 在模拟流量过程中,工程门表现出正确的开放,但观察到的闭合动态不足最佳.
- 低于最佳的闭合被归因于较低程度的组织异构性,而不是与原生大动脉膜传单相比.
结论:
- 成功开发了使用人静脉细胞和可生物降解的支架的自身组织工程心脏门.
- 观察到的组织特性和机械行为表明,有可能被用作活体大动脉置换.
- 需要进一步优化组织异构性,以完全复制本源大动脉功能.
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