节奏诱导的异步预先条件 子心肌对抗缺血症/再输液损伤
Ward Y Vanagt1, Richard N Cornelussen, Quincy P Poulina
1Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht, Netherlands. ward.vanagt@fys.unimaas.nl
Circulation
|July 6, 2006
概括
心室节奏 (VP) 诱导心脏失调,提供与缺血预先调节 (IPC) 相比的心脏保护. 这表明拉伸介导信号,而不是缺血,触发VP保护,在心脏外科手术中具有潜在的应用.
科学领域:
- 心脏病学 心脏病学
- 身体生理学 身体生理学
背景情况:
- 增加的机械负载可以诱导预先调节 (PC).
- 心脏失调会增加晚期激活区域的机械负荷.
- 调查心脏保护作用的心室节奏 (VP) 诱导的异步.
研究的目的:
- 为了确定心室节奏 (VP) 诱导的异步是否能提供心脏保护.
- 为了比较VP诱导的异步与缺血预先调节 (IPC) 的心脏保护作用.
主要方法:
- 隔离工作子的心脏经历了缺血和再输血.
- 组包括VP预先调节 (VP PC),缺血性预先调节 (IPC) 和控制 (C).
- 评估了全球血液动力学,细分工作,细分长度,心脏病发作大小和proBNP mRNA表达.
主要成果:
- 与对照组相比,VP PC和IPC显著减少了心脏病发作的大小.
- VP PC诱导的异步,改变了左心室 (LV) 肌肉中的细分工作和长度.
- VP PC显著增加了前后LV心肌中的亲BNPmRNA表达.
结论:
- 通过VP间歇性失调与经典IPC一样具有心脏保护作用.
- 伸展介导信号是比缺血更有可能触发VPPC的原因.
- VP PC证明了在心脏外科手术中的潜在适用性.
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