血液是否优于结晶性心脏? 一个随机临床试验的元分析
Veena Guru1, John Omura, Abdullah A Alghamdi
1Division of Cardiovascular Surgery, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, H-410, Toronto, Ontario M4N 3M5 Canada. veena.guru@utoronto.ca
血液心脏显著减少低输出综合征和心脏手术后早期心脏酶释放. 然而,心肌梗塞和死亡率与水晶性心脏相比仍然相似.
科学领域:
- 心脏病学 心脏病学
- 心脏外科手术 心脏外科手术
- 患有心脏的情况.
背景情况:
- 许多小型试验已经比较了血液与晶体性心脏,以保护心肌.
- 血液心脏模仿生理条件,可能提供临床优势.
研究的目的:
- 对血液心脏的有效性进行随机对照试验进行元分析.
- 评估血液心脏对不良术后结果的影响.
主要方法:
- 系统地搜索MEDLINE,EMBASE和Cochrane注册表中的相关试验.
- 包括同行评审的,英语随机对照试验在成年患者.
- 由两个独立的审稿人提取和评估;随机效应建模用于分析.
主要成果:
- 血液心肌显著降低了低输出综合征 (LOS) (OR,0.54;P=0.006).
- 24小时后手术后的CKMB释放与血液心脏性减少 (平均差异5.9U/L;P=0.007).
- 心肌梗塞和死亡的发生率在各组之间没有显著差异.
结论:
- 与水晶性心脏相比,血液心脏提供了优越的心肌保护.
- 较低的LOS率和早期的CKMB增加在血液心脏中观察到.
- 类似的心肌梗塞和死亡率表明可比的长期结果.
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