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在患有法洛特四重症的儿童中,右心室适应失败
Sushma Reddy1, Juan Carlos Osorio, Ana M Duque
1Division of Pediatric Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA.
Circulation
|July 6, 2006
概括
患有法洛四重症 (TOF) 的儿童的右心室 (RV) 无法适应缺氧,因为它无法调节保护基因. 这种不适应反应可能会影响长期的RV功能.
科学领域:
- 心血管生物学 心血管生物学
- 儿童心脏病学 儿童心脏病学
- 分子医学是分子医学.
背景情况:
- 左心室 (LV) 通过基因表达适应慢性缺氧,以改善O2输送和减少损伤.
- 右心室 (RV) 对患有法洛四重症 (TOF) 的儿童缺氧的适应能力仍然没有特征.
研究的目的:
- 为了研究RV的基因表达对TOF的儿科患者缺氧的反应.
- 为了比较阴阳性和阴阳性TOF组之间的适应性基因表达.
主要方法:
- 实时聚合酶链反应 (PCR) 用于测量23名TOF患者的RV心肌中的基因表达.
- 基因表达水平在蓝色和无蓝色组之间进行了比较,并与临床参数相关联.
主要成果:
- 蓝色的TOF患者表现出较低的血管性 (VEGF),甘油性和抗氧化剂 (GPX) 基因表达,和较高的原体表达与蓝色的患者相比.
- 基因表达的变化与病的严重程度 (血) 相反相关,与氧和相对正相关.
- 适应性基因的减少表达与术后乳酸水平的增加相关.
结论:
- 患有TOF的儿童的RV表明,在对低氧的反应中,无法调节适应性基因表达途径.
- 这种早期不适应的VR反应对心脏功能的长期后果需要进一步调查.
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