S2连接器与接器:偏远冠状动脉缩重塑,通透性和猪的功能
Willem J L Suyker1, John P Matonick, Paul T W Suyker
1Cardiothoracic Surgeon, Isala Klinieken (Location: Weezenlanden, Groot Wezenland 20), P.O. Box 10500, 8000 GM Zwolle, Netherlands. w.suyker@isala.nl
Circulation
|July 6, 2006
概括
一种新型冠状动脉连接器显著减少了绕道手术的时间,并在猪模型中表现出优异的长期通透性和功能,优于传统接.
科学领域:
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
- 手术设备 手术设备
背景情况:
- 最少入侵的绕道手术需要有效的静脉动脉技术.
- 对于冠状动脉旁路移植 (CABG) 的传统接方法是耗时的.
- 开发了一种新型的内冠状动脉连接器 (S2AS),以潜在地改善CABG程序.
研究的目的:
- 评估与传统接相比,新型远端冠状动脉连接器的安全性和有效性.
- 评估S2AS连接器在冠状动脉旁路中的性能.
- 为了确定S2AS连接器与标准接技术的等价性.
主要方法:
- 在35头猪身上进行了脱冠状动脉旁路.
- 使用S2AS内连接器 (n=21) 或常规接 (n=14) 创建了解剖体.
- 在手术期间和手术后90天和180天评估了解剖.
主要成果:
- S2AS解剖构造显著更快 (3.7分钟与16.5分钟相比,P<0.001).
- 在180天后实现了100%的通透性,具有出色的血液动力学性能 (FFR ≥0.93).
- 与6个月后的 sutures 相比,S2AS连接器导致较少的光线损失和更薄的neointima.
结论:
- 该S2AS连接器可实现快速,高质量的解剖,符合当前的通透性和功能标准.
- 连接器的设计,包括不合规的环和配置变化,并没有妨碍有利的改造.
- 这些发现表明,在绕道外科手术中实现解剖穿透性的新解剖考虑.
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