患有慢性阻塞性肺病的患者经历冠状动脉旁路手术的长期存活率
Bruce J Leavitt1, Cathy S Ross, Brian Spence
1Fletcher Allen Health Care, 111 Colchester Ave, Burlington, VT 05401-1473, USA. bruce.leavitt@vtmednet.org
Circulation
|July 6, 2006
概括
患有慢性阻塞性肺病 (COPD) 且接受冠状动脉旁路手术 (CABG) 的患者的长期存活率降低. 结合其他并发性疾病的COPD可显著恶化CABG后的生存结果.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 外科手术的结果
背景情况:
- 慢性阻塞性肺病 (COPD) 与冠状动脉旁路手术 (CABG) 后的住院死亡率较高有关.
- 在CABG后的COPD患者的长期存活数据有限.
- 这项研究调查了COPD对CABG后长期生存的影响.
研究的目的:
- 为了评估经过冠状动脉旁路手术 (CABG) 的患者的长期生存率.
- 具体评估慢性阻塞性肺病 (COPD) 对CABG后生存的影响.
- 为了比较没有并发症,单独COPD,其他并发症和COPD与其他并发症的患者的生存结果.
主要方法:
- 对33137名隔离CABG患者 (1992-2001) 的前性研究.
- 通过将记录与国家死亡指数联系而获得的长期死亡数据.
- 考克斯比例危险回归用于确定危险比率 (HR) 并调整伴随性疾病.
主要成果:
- 总的死亡发生率为每100人年4.1.
- 根据并发症状况,生存率有显著差异 (日志等级P<0.001).
- 单独的COPD (HR 1.8) 和其他并发症 (HR 2.2) 与没有并发症相比,显著降低了存活率. 患有COPD和其他并发症的患者的生存率最差 (HR 3.6).
结论:
- 单独患有慢性阻塞性肺病 (COPD) 的患者在冠状动脉旁路手术 (CABG) 后的长期存活率显著降低,与没有并发症的患者相比.
- 结合一个或多个其他并发症的COPD存在导致CABG后最差的长期存活率.
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