在扩张性心肌病症中进行 mitra 叶片重塑
Tomasz A Timek1, David T Lai, Paul Dagum
1Department of Cardiothoracic Surgery, Stanford University School of Medicine Stanford, California 94305-5247, USA.
Circulation
|July 6, 2006
概括
慢心症引起的心肌病导致额头门的叶片延长,这是由于边缘附近的重塑,而不是绑定或改变形状. 这种重塑与心肌病中额头肌反有关.
科学领域:
- 心血管研究研究心血管研究
- 心脏机械学 心脏机械学
- 生物医学工程 生物医学工程
背景情况:
- 哺乳动物中枢的说明书在组成和结构上表现出区域差异.
- 扩张性心肌病对 mitrale 叶片形状和几何学的影响尚不清楚.
研究的目的:
- 为了研究心动节拍诱导心肌病 (TIC) 如何影响二手心小册子的形状,几何学和区域重塑.
- 为了确定是否发生在TIC诱导的功能性额头吐 (FMR) 中的传单绑定或显著的形状变化.
主要方法:
- 在九只绵羊中植入了在二手环和传单上的无线不透明标记.
- 诱导心肌病症和通过快速节奏的功能性 mitra 反.
- 利用双平面视频光学和心声回声学来测量传单的长度,段长度和位移.
主要成果:
- 前额关节叶片 (AML) 和后额关节叶片 (PML) 的总长度在节拍后显著增加.
- 只有在边缘附近的叶片段 (AML S4和PML S5) 才观察到显著的区域重塑.
- 没有检测到AML形状或传单结合的变化.
结论:
- 动脉动引起的心肌病导致伴心叶片通过叶片边缘的区域重塑而延长.
- 在心肌病中,心交吐涉及到小册子重塑,挑战FMR的纯粹"功能性"解释.
- 研究结果表明,心肌病中美肌管吐的结构基础超出了简单的环状扩张.
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