Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

GPCR Desensitization01:12

GPCR Desensitization

6.1K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
6.1K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

3.4K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.4K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

3.5K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.5K
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

2.0K
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
2.0K
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

1.4K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.4K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

820
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
820

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mitral valve abscess: echocardiographic imaging, microbiology, management, and outcomes.

European heart journal. Imaging methods and practice·2026
Same author

Mitral valve repair after failed transcatheter edge-to-edge repair: Approach and strategies for success.

JTCVS techniques·2026
Same author

Decision-making in mitral valve repair: Crucial points from 3 posterior leaflet cases.

JTCVS techniques·2026
Same author

Internal mammary artery grafting: The gold standard of coronary revascularization for 40 years and counting.

The Journal of thoracic and cardiovascular surgery·2026
Same author

The Society of Thoracic Surgeons Expert Consensus Pathway for Robotic Cardiac Surgical Training.

The Annals of thoracic surgery·2026
Same author

The "VertebroSternal Window": Implications in Minimally Invasive Surgery.

The Annals of thoracic surgery·2026

相关实验视频

Updated: May 2, 2026

Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 2, 2010

34.1K

在三管解剖手术后复发或残留的功能性三管吐的决定因素

Shota Fukuda1, A Marc Gillinov, Patrick M McCarthy

  • 1Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F15, Cleveland, Ohio 44195, USA.

Circulation
|July 6, 2006
PubMed
概括

三管的修复耐用性受到小册子连接,左心室和右心室功能以及压力的影响. 这些因素预测三管吐术后的三管吐复发,指导手术策略.

更多相关视频

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
17:35

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

Published on: November 2, 2013

38.9K
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

4.7K

相关实验视频

Last Updated: May 2, 2026

Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 2, 2010

34.1K
A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
17:35

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

Published on: November 2, 2013

38.9K
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
08:39

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents

Published on: May 16, 2022

4.7K

科学领域:

  • 心脏病学 心脏病学
  • 心脏外科手术 心脏外科手术
  • 心声回声扫描 (Echocardiography) 是一种心声回声扫描.

背景情况:

  • 通过结婚整形手术修复三管 (TV) 的耐久性有限.
  • 经常性或残留的三回 (TR) 机制需要识别,以改善电视修复结果.

研究的目的:

  • 调查电视取消造形术后的中期结果的回声心脏学决定因素.

主要方法:

  • 在39名具有功能TR的患者中,心声扫描在手术前,手术后早期和TV解体术后1年进行.
  • 测量包括TR严重程度,TV环形尺寸,小册子位移,左心室 (LV) 功能和右心室 (RV) 功能和压力.

主要成果:

  • 手术前的传单绑定高度和区域预测了早期和中期的结局.
  • 早期术后的LV喷射分数和TR严重程度影响TR程度在1年以上.
  • 在后期随访期间,增加的RV压力与更糟糕的TR相关.

结论:

  • 电视连接是经常性TR的关键决定因素.
  • LV和RV的功能和压力显著影响三管的修复耐用性.
  • 识别有风险的患者需要改进手术策略和密切的术后监测.