尺寸不足的 mitra annuloplasty 对区域横向左心室壁应变和壁加厚机制的影响
Allen Cheng1, Tom C Nguyen, Marcin Malinowski
1Department of Cardiovascular and Thoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5247, USA.
Circulation
|July 6, 2006
概括
低尺寸的 mitra annuloplasty 通过损害纤维缩短和薄膜加厚,减少了缩前区域的缩壁的加厚. 这种手术可能会对局部心肌力学产生负面影响,特别是在心肌环附近.
科学领域:
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
- 心脏机械学 心脏机械学
背景情况:
- 低尺寸的 mitra annuloplasty 用于 mitra regurgitation (MR) 并旨在改善左心室 (LV) 的形状.
- 之前的研究表明,它可能会抑制靠近 mitra annulus 的缩面壁加厚.
- 这项研究研究了对区域跨壁 LV 墙壁力学的影响.
研究的目的:
- 为了测量低尺寸的头骨除术对区域跨壁LV壁纤维和板状纤维菌株的影响.
- 为了分析结缩性壁加厚的机制,后 annuloplasty.
主要方法:
- 九只绵羊在底前和侧方赤道LV区域进行了放射性不透明珠子组的手术插入.
- 四维视频光学跟踪了在 mitra annuloplasty 之前和之后的标记器动态.
- 计算了横向的线条 (周边,纵向,辐射) 并将其转换为纤维,板和板正常坐标.
主要成果:
- 在所有深度下,低尺寸的结核整形术减少了50%以上的前骨干静脉壁加厚.
- 这种减少是由于抑制的下内心纤维缩短和缩板的加厚.
- 在偏远的横向赤道区域中,没有观察到纤维板拉伸或墙壁加厚的显著变化.
结论:
- 低尺寸的 mitra annuloplasty 敏地抑制了静脉壁在前骨基LV区域的加厚.
- 抑制的结果是减少心下内膜纤维的缩短和层状板的加厚.
- 这些发现表明,低尺寸的结核整形术对局部心肌力学有潜在的有害影响.
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