在血液中预症状检测血质子
Paula Saá1, Joaquín Castilla, Claudio Soto
1George and Cynthia Mitchell Center for Alzheimer's Disease Research, Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0646, USA.
概括
研究人员检测出了子蛋白质 (PrPSc) 在血的血中,在预症状阶段的甲虫病. 这一发现为早期诊断传染性海绵状脑病变 (TSEs) 提供了一种有希望的非侵入性方法.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 生物化学 生物化学
背景情况:
- 传染性海绵状脑病变 (TSEs) 是由子引起的致命的神经退行性疾病.
- 子,特别是异常的子蛋白 (PrPSc),是TSE的传染病原体.
- 敏感检测PrPSc对于疾病控制和预防至关重要.
研究的目的:
- 为了调查虫感染子的血液中PrPSc的存在和来源.
- 评估基于血液的PrPSc检测对于TSE早期,非侵入性诊断的潜力.
主要方法:
- 生物化学检测PrPSc在实验性感染黄病的仓鼠血液中.
- 分析整个潜伏期PrPSc的存在,包括症状前和症状阶段.
主要成果:
- 在大多数症状前疾病阶段,在受感染的仓鼠的血液中生物化学检测到PrPSc.
- 在化期早期,血液PrPSc很可能起源于外围子复制.
- 在症状阶段,血液PrPSc更多地表明从大脑泄漏.
结论:
- 血液中PrPSc的生物化学检测是可行的在scrapie的前症状阶段.
- 血液PrPSc检测对TSE的非侵入性早期诊断具有显著的前景.
- 了解血液的起源PrPSc有助于理解子的病原性.
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